Jan 17, 2024 · We focus on the interaction of the lung microbiome with the oropharynx and gut microbiome and emphasize the role it plays in the innate and adaptive immune responses. More importantly, we focus...

Many studies have found significant differences in microbial composition between during health and respiratory disease. The lung microbiome is likely to not only influence susceptibility or causes of diseases but be affected by disease activities or responses to treatment.

Nov 16, 2022 · In this Review, we provide an overview of lower airway microbial dynamics in health and disease and discuss future work that is required to uncover novel therapeutic targets to improve lung...

It consists of a core of nine genera: Prevotella, Sphingomonas, Pseudomonas, Acinetobacter, Fusobacterium, Megasphaera, Veillonella, Staphylococcus, and Streptococcus. [1][2][3] They are aerobes as well as anaerobes and aerotolerant bacteria.

Mar 11, 2025 · The lung microbiome is shaped by environmental exposures, anatomical features, and host factors that regulate microbial colonization. Unlike the gut, where a stable microbial community thrives, the lungs experience continuous microbial fluctuation due to airflow and mucociliary clearance.

Jun 16, 2022 · Once thought to be sterile, the human lung is now well recognized to harbor a consortium of microorganisms collectively known as the lung microbiome.

Aug 2, 2021 · This Review highlights features of the lung microbiome, unique considerations in studying it, examples of dysbiosis in selected disease, emerging concepts in lung microbiome-host interactions, and critical areas for investigation.

Apr 15, 2024 · Our advancing knowledge of the lung microbiome will provide disease targets in acute and chronic lung disease and may facilitate the development of new therapeutic strategies. Microbes have dominated life on our planet, predating …

Jul 9, 2015 · The composition of the lung microbiome is, by first principles, determined by the balance of three factors : (1) microbial immigration into the airways, (2) elimination of microbes from the airways, and (3) the relative reproduction rates of its community members, as determined by regional growth conditions. Any change in the microbiome ...

With this backdrop, we have chosen to explore what is known about the potential role of the microbiota (both gut and lung) and host interaction in regulating the pathogenesis of several important lung diseases. Origins of lung microbiome and debunking lung sterility