Everything you need to know about the Rams' home game against the NFC West rival San Francisco 49ers, including start time, ...

Jimmy Garoppolo knows what it feels like as a San Francisco 49er to come to L.A., but now the quarterback is on the other ...

The 49ers are partly to blame for why Christian McCaffrey will be out at least four games and possibly more as he nurses ...

The 49ers woes in Minnesota continued last week when their former quarterback Sam Darnold torched his old squad. The offense ...

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

McCaffrey won NFL Offensive Player of the Year in 2023 and helped the 49ers reach Super Bowl 58. He’s produced 2,205 rushing ...

San Francisco had its toughest practice of the week Thursday and McCaffrey was dealing with pain afterward, Shanahan said.

The San Francisco 49ers are without running back Christian McCaffrey for at least four weeks. A report from NFL Media’s Ian ...

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...

ESPN sources: 49ers officially are placing All-Pro RB Christian McCaffrey on injured reserve due to his calf tightness and ...

The San Francisco 49ers have ruled out Christian McCaffrey for Week 2 vs. the Minnesota Vikings — and potentially longer.

The San Francisco 49ers will be missing two of their biggest playmakers when they visit SoFi Stadium on Sunday to face the ...