San Francisco 49ers star linebacker Fred Warner revealed that he has been playing through a broken bone in his ankle since ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

San Francisco 49ers head coach Kyle Shanahan told reporters that star quarterback Brock Purdy will practice with the team ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The banged-up San Francisco 49ers received some positive news on Wednesday. Per ESPN's Nick Wagoner, 49ers head coach Kyle ...

The Packers dominated the 49ers 38-10, highlighting major defensive issues and lackluster player performance. San Francisco ...

The San Francisco 49ers have reportedly emerged as a strong candidate to sign free-agent quarterback Daniel Jones. According ...

San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

Buffalo Bills team reporter Maddy Glab joins 1st & 10 to breakdown the 49ers-Bills matchup, discuss what to expect on "SNF" ...

DE Leonard Floyd returns to Buffalo for the first time since leaving the Bills in free agency to sign with the 49ers in March. Floyd is playing his best ball of late with 3 1/2 sacks the past two ...

The San Francisco 49ers have opened the practice window for linebacker Dre Greenlaw from the Reserve/Physically Unable to ...