Bosa (hip/oblique) has been ruled out for Sunday's game against Buffalo, Lindsey Pallares of the 49ers ' official site reports.

The 5-6 San Francisco 49ers are preparing to go head-to-head with a 9-2 Buffalo Bills team on Sunday night. San Francisco is ...

The San Francisco 49ers got a taste of what their defense looks like without Nick Bosa in the second half of a loss to the ...

This week, Nick Bosa was asked about the 49ers' upcoming opponent, Bills quarterback Josh Allen. Here's what Bosa said. Q: ...

The 49ers won't have their best pass rusher when they face the Bills on Sunday. Nick Bosa will miss his second game in a row with an oblique injury ...

San Francisco 49ers star Deebo Samuel had a blunt reaction when asked about his low numbers to begin this season.

The San Francisco 49ers are expecting to get star tight end George Kittle back this week for a key game against Green Bay, ...

The San Francisco 49ers have battled a number of extensive injuries during the 2024-2025 NFL season. And they got more bad news on Friday night, as they learned that both Nick Bosa and Brock Purdy ...

The Bills attempt to win seven in a row when they host the 49ers in this Week 13 NFL odds, prediction, and pick.

The 49ers are taking stock of their injury situation but could be getting some key players back for Buffalo game.

Quarterback Brock Purdy threw without pain Monday and 49ers coach Kyle Shanahan will wait until midweek to determine the progress of edge rusher Nick Bosa and left tackle Trent Williams.

The 49ers needed to be better than they’ve been all season without Purdy, Bosa and Williams. Instead, they were worse.