The San Francisco 49ers may soon lose one of their best offensive players to the Minnesota Vikings in free agency.

ORCHARD PARK, NEW YORK – DECEMBER 01: Mack Hollins #13 of the Buffalo Bills celebrates after scoring a touchdown in the ...

Add in All Leagues ROSTERED IN: 5% of Yahoo Leagues ANALYSIS: San Francisco 49ers running back Isaac Guerendo is the RB63 for ...

San Francisco 49ers coach Kyle Shanahan is sharing an update on Trent Williams and his family after the left tackle's son was ...

The San Francisco 49ers season turned into chaos after they suffered their third consecutive loss, the last two in crushing ...

The San Francisco 49ers' season has been on the brink for weeks, and the Week 13 blowout loss to the Buffalo Bills certainly ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

San Francisco 49ers' Trent Williams and his wife, Sondra, mourn the loss of their stillborn twin son, Trenton O'Brien ...

The Series: The 70th game between the teams. The 49ers lead 35-33-1. San Francisco is 22-14 at home in the series. The Bears ...

The Bills are a Super Bowl contender and the 49ers somehow probably aren’t even a playoff team. That’s how Sunday night’s ...

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian ...

Williams’ wife, Sondra, announced on Instagram on Sunday, Dec. 1 that their son Trenton O'Brien Williams Jr. was stillborn on ...