Joe Mixon had a huge Wild Card playoff game for the Houston Texans against the Los Angeles Chargers — he ran for 106 yards and touchdown on 25 carries. But an ankle injury popped up this week, with reports that he practiced a bit on Wednesday and wasn’t on the field for Thursday’s walkthrough, per Texans Wire.

Houston Texans running back Joe Mixon has been a workhorse for the team during the 2024-2025 season. The veteran totaled 245 carries during the regular season and added another 25 carries in last week's playoff win over the Los Angeles Chargers.

Joe Mixon is active for the Houston Texans’ divisional playoff game against the Kansas City Chiefs. The Pro Bowl running back had shown up on the injury report with an ankle problem and missed practice late in the week.