Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

San Francisco 49ers coach Kyle Shanahan is sharing an update on Trent Williams and his family after the left tackle's son was ...

The San Francisco 49ers may soon lose one of their best offensive players to the Minnesota Vikings in free agency.

A Bills equipment cart awkwardly interrupted an NBC Sports Bay Area live segment after the 49ers' loss in Buffalo.

The Series: The 70th game between the teams. The 49ers lead 35-33-1. San Francisco is 22-14 at home in the series. The Bears ...

Williams’ wife, Sondra, announced on Instagram on Sunday, Dec. 1 that their son Trenton O'Brien Williams Jr. was stillborn on ...

San Francisco 49ers' Trent Williams' wife Sondra has announced the death of their baby son at 35 weeks after losing his twin ...

The San Francisco 49ers could be nearing the end of a long run as title contenders. Not only are the 49ers now in last place ...

Star pass-catcher George Kittle and the San Francisco 49ers play the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

Sondra Williams, the wife of San Francisco 49ers pro offensive tackle Trent Williams, announced the tragic death of their ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

A pair of Super Bowl hopefuls from each conference meet up on Sunday, Dec. 1 to close out the NFL schedule for the day with ...