The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock Purdy. Backup quarterback Brandon

After that, there is no significant NFL talent on the 49ers roster, while the edges are equally deficient in both depth and run-stopping abilities. For that reason, the Bills may pursue interior runs early and often while San Francisco struggles to find ...

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff from Highmark Stadium is set for 8:20 p.m. ET (NBC). Let's analyze BetM

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks and NFL predictions

Star pass-catcher George Kittle and the San Francisco 49ers meet the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark Stadium.The Bills sport the seventh-ranked defense this season (19.5 points

Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

Player prop bets will be available for Josh Allen ahead of Sunday’s NFL action at 8:20 PM ET live on NBC. The Buffalo Bills (9-2) and Allen face off versus the San Francisco 49ers (5-6) in a

After games on both Thanksgiving and Black Friday, the NFL caps off the Sunday slate with the Buffalo Bills hosting the San Francisco 49ers. Buffalo's fresh off a bye following a statement win against the two-time defending champion Kansas City Chiefs.

The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at 5:20 p.m. PT. The Bills

Black Friday has come and gone, but we're still trying to shop for value in the Week 13 slate. We've tracked line moves for every NFL game this week since Monday morning at BetMGM Sportsbook. Below, we'll analyze how injuries have shaped the market and where sharp bettors have found Black Friday deals throughout the week.