GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.
Cells can measure how long they spend in mitosis. If mitosis is prolonged due to problems during chromosome separation, the Mitotic Stopwatch Complex is formed, which may lead to cell arrest or cell ...
Replication origins in eukaryotic cells initiate a single round of DNA synthesis in each cell cycle. This requires the regulated binding of several conserved initiation proteins, including CDC6/Cdc18p ...
Unraveling metabolic regulation in aneuploid tumor cells: Key insights for targeted cancer therapies
A research team led by Professor YANG Zhenye from the Division of Life Sciences and Medicine, the University of Science and Technology of China (USTC) of Chinese Academy of Sciences (CAS), in ...
Cell division is a precise process, but sometimes it can be impaired, allowing diseases such as cancer to develop. Researchers at Okinawa Institute of Science and Technology (OIST) in collaboration ...
Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...
Researchers have found a molecular mechanism that prevents multiplication of potentially dangerous cells by measuring the duration of mitosis. They have shown that this mechanism -- the Mitotic ...
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