Cyclic peptides often exhibit low membrane permeability which can be significantly improved via amide-to-ester substitutions—as demonstrated by researchers from Tokyo Institute of Technology (Tokyo ...

Small-molecule drugs have been instrumental in alleviating a gamut of ailments, from heart disease to the humble headache, but some experts now think we’ve exhausted the number of targets those drugs ...

There has been a recent revival in interest in peptide therapeutic development, with five of the top-selling drugs being peptides or proteins (Enbrel, Remicade, Humira, Avastin, MabThera) and many ...

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat ...

FUJIFILM Corporation announces the successful validation of the cancer cell-targeting potential of its peptide-oligonucleotide conjugates. This validation resulted from combining oligonucleotides with ...

A discovery could speed up efforts to produce new antibiotics in the fight against antimicrobial resistance. A discovery made by scientists at King's College London could speed up efforts to produce ...

Peptide nanotubes result from the self-assembly of cyclic peptides, which are structured from alternating D- and L-amino acids. This assembly leads to stable beta-sheet formations that curl into ...

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat ...

1910 is on a mission to “make undruggable targets a thing of the past” by “turning every pharma company into an AI company,” says founder and CEO, Jen Asher, PhD. The Sam Altman–backed AI drug ...