Recent studies show that redox-active small molecules are selectively cytotoxic to chronic lymphocytic leukemia (CLL). Although elevated levels of reactive oxygen species in CLL cells have been ...

Reactive electrophilic drugs like Tecfidera, approved for the treatment of relapsing multiple sclerosis, show a lot of potential but are also mystery. Scientists have now used an innovative chemical ...

In 2014, the European Medicines Agency approved the drug Tecfidera for the treatment of relapsing multiple sclerosis, a neurodegenerative disease that affects millions of people worldwide. In multiple ...

In general, an electrophile is a highly reactive compound that “seeks” to bond with atoms or other molecules that have an available electron pair. In the buzzing hive of activity that is the cell, ...

Scientists generalize the synthesis of aminating agents to simplify the design and manufacture of drugs and other fine chemicals in which nitrogen atoms play key roles. Each of these agents contains ...

Collaboration will leverage Flare Therapeutics' proteomic and mass spectrometry platform and expertise, powered by its proprietary library of electrophilic compounds, to discover novel small molecules ...