Move over, amyloid, reactive astrocytes and activated microglia may be the main drivers of the Alzheimer’s disease pathological cascade. In the November 6 Nature Neuroscience, scientists led by Pedro ...
Neurodegenerative disease and cognitive decline cannot be explained by a single process. Beta-amyloid plaques, hyperphosphorylated tau, alpha-synuclein, activated microglia and astrocytes, altered ...
A study by Dorothy P. Schafer, Ph.D., and Travis E. Faust, Ph.D., at UMass Chan Medical School, explains how two different cell types in the brain—astrocytes and microglia—communicate in response to ...
Clusterin, we’re sorry—we misjudged you. Long cast as Aβ’s villainous sidekick (Jan 2014 news; Apr 2023 news), the chaperone now looks more like a friendly superhero. Provided, that is, our genes let ...
A single treatment of viral vector-delivered CAR-A construct in mice with existing plaque saturation cut the amount of amyloid plaques in half.
Until now, conventional 3D cell cultures have often been either too rigid or too unstable to realistically reproduce the ...
The new generation of Alzheimer's disease drugs—the first proven to change the course of the disease—typically extend independent living for patients by 10 months. Called monoclonal antibodies, they ...
The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system. Microglia, the primary immune cells of the central ...
When we learn a new motor skill—whether mastering a piano passage or refining balance while walking—the brain must reorganize the circuits that control movement. For decades, this process of synaptic ...
When we learn a new motor skill—whether mastering a piano passage or refining balance while walking—the brain must reorganize the circuits that control movement. For decades, this process of synaptic ...
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